The Italian coach said he knows the Ukrainian's abilities well, having previously worked with him at Shakhtar Donetsk.
"I worked with Misha before, at the beginning of his career, so I know very well what he can bring to our team.
"I will demand a lot from Misha, and our job is to help him become the best version of himself. If we can do that, he can become a very important player for us. I am very happy that he chose our club, and I can't wait to work with him again," Tottenham's press service quoted De Zerbi as saying.
Tottenham announced the loan signing of the 25-year-old Ukrainian from Chelsea. The deal includes an option to buy the player for 75 million pounds ($87.5 million).
De Zerbi coached Mudryk at Shakhtar during the 2021-22 season. Under him, the Ukrainian made 19 appearances, scoring two goals and providing six assists.
In August, after Mudryk's suspension for violating anti-doping rules was lifted, De Zerbi said the Ukrainian was "like a son" to him.
After his suspension was lifted, Mudryk joined Chelsea in Hong Kong for the club's preseason training camp and played in a friendly against Juventus, coming on as a substitute in the second half. It was Mudryk's first match since November 2024.
Earlier, Mykhailo Mudryk spoke about his emotions after reuniting with head coach Roberto De Zerbi.